Structure of PDB 8y8b Chain A

Receptor sequence
>8y8bA (length=271) Species: 443241 (Human coronavirus HKU1 (isolate N5)) [Search protein sequence]
VIGDFNCTNSFINDYNKTIPRISEDVVDVSLGLGTYYVLNRVYLNTTLLF
TGYFPKSGANFRDLALKGSIYLSTLWYKPPFLSDFNNGIFSKVKNTKLYV
NNTLYSEFSTIVIGSVFVNTSYTIVVQPHNGILEITACQYTMCEYPHTVC
KSKGSIRNESWHIDSSEPLCLFKKNFTYNVSADWLYFHFYQERGVFYAYY
ADVGMPTTFLFSLYLGTILSHYYVMPLTCNAISSNTDNETLEYWVTPLSR
RQYLLNFDEHGVITNAVDCSS
3D structure
PDB8y8b TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
ChainA
Resolution3.01 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MJJ A N26 Y28 L79 K80 S82 Y84 W89 S246 N13 Y15 L66 K67 S69 Y71 W76 S233
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y8b, PDBe:8y8b, PDBj:8y8b
PDBsum8y8b
PubMed38964329
UniProtQ0ZME7|SPIKE_CVHN5 Spike glycoprotein (Gene Name=S)

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