Structure of PDB 8y6b Chain A

Receptor sequence
>8y6bA (length=486) Species: 9606 (Homo sapiens) [Search protein sequence]
NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLK
TRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSG
SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIIS
DKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGA
CLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQD
SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDG
YSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGN
CGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT
LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSS
KEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN
3D structure
PDB8y6b Structure of human LGI1-ADAM22 complex in space group P212121
ChainA
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E242 D325 C433 N436 E10 D93 C201 N204
BS02 CA A R504 D511 I512 E514 N526 I527 R272 D279 I280 E282 N294 I295
BS03 CA A E446 N449 F451 E456 D459 E214 N217 F219 E224 D227
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8y6b, PDBe:8y6b, PDBj:8y6b
PDBsum8y6b
PubMed
UniProtQ9P0K1|ADA22_HUMAN Disintegrin and metalloproteinase domain-containing protein 22 (Gene Name=ADAM22)

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