Structure of PDB 8y65 Chain A

Receptor sequence
>8y65A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence]
CSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDP
DTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAAL
LMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQ
VTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLP
DSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVS
VLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKI
PYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLT
LQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFII
AGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETK
NRTYAEISQAFSKRNKA
3D structure
PDB8y65 Structural basis for urate recognition and apigenin inhibition of human GLUT9.
ChainA
Resolution3.51 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URC A Y327 L332 N333 W336 Y274 L279 N280 W283
Gene Ontology
Molecular Function
GO:0005351 carbohydrate:proton symporter activity
GO:0005353 fructose transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015149 hexose transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0008645 hexose transmembrane transport
GO:0015747 urate transport
GO:0015749 monosaccharide transmembrane transport
GO:0015755 fructose transmembrane transport
GO:0046415 urate metabolic process
GO:1902600 proton transmembrane transport
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y65, PDBe:8y65, PDBj:8y65
PDBsum8y65
PubMed38866775
UniProtQ9NRM0|GTR9_HUMAN Solute carrier family 2, facilitated glucose transporter member 9 (Gene Name=SLC2A9)

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