Structure of PDB 8y22 Chain A

Receptor sequence
>8y22A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
GVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV
TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY
VIVEYASKGNLREYLQARRPPEEQLSSKDLVSCAYQVARGMEYLASKKCI
HRDLAARNVLVTEDNVMKIADFGLARIDYYKKTTNGRLPVKWMAPEALFD
RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSN
CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS
3D structure
PDB8y22 Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.
ChainA
Resolution2.792 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LW9 A L484 E486 C488 K514 E531 I545 V561 E562 Y563 A564 L630 A640 D641 F642 L26 E28 C30 K56 E73 I87 V103 E104 Y105 A106 L160 A170 D171 F172
External links
PDB RCSB:8y22, PDBe:8y22, PDBj:8y22
PDBsum8y22
PubMed38870833
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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