Structure of PDB 8xz7 Chain A

Receptor sequence
>8xz7A (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG
PLYVIVEYASKGNLREYLQARRPPGLEYSYNQLSSKDLVSCAYQVARGME
YLASKKCIHRDLAARNVLVTEDNVMKIADFGLAHIDYYKKTTNGRLPVKW
MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG
HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
3D structure
PDB8xz7 Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.
ChainA
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LWW A L484 E486 C488 F489 A512 K514 E531 M535 Y563 A564 L630 D641 F642 L29 E31 C33 F34 A57 K59 E76 M80 Y108 A109 L168 D179 F180
External links
PDB RCSB:8xz7, PDBe:8xz7, PDBj:8xz7
PDBsum8xz7
PubMed38870833
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

[Back to BioLiP]