Structure of PDB 8xya Chain A

Receptor sequence
>8xyaA (length=986) Species: 9606 (Homo sapiens) [Search protein sequence]
RSRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSI
LAVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVES
FKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTAS
GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASS
VGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRAST
SKEVDASLLSVVSFPAFAVEDSQLVELTKQEIITKLQGRYGCCRFLRDGY
KTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEY
KEALEAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHM
WGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEI
KTILKDKGIYVETIAEVYPIRVQPARILSHIYSSLGCNNRMKLSGRPYRH
MGVLGTSKLYDIRKTIFTFTPQFIDQQQFYLALDNKMIVEMLRTDLSYLC
SRWRMTGQPTITFPISHSMLDEDGTSLNSSILAALRKMQDGYFGGARVQT
GKLSEFLTTSCCTHLSFMDPEVARYLDHLLAEQADILYMLYTMKGPDWNT
ELYNLLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL
TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMY
MRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAM
KNLLHHILSGKEFQGQWQRRRRLDGALNRVPVGFYQKVWKVLQKCHGLSV
EGFVLPSSTTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTML
ADIEIHSIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTL
LYDSAPSGRFGTMTYLSKAAATYVQEFLPHSICAMQ
3D structure
PDB8xya Architecture and activation of human muscle phosphorylase kinase
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAR A K1081 L1137 A1138 E1141 V1211 C1220 K844 L900 A901 E904 V974 C983
Gene Ontology
Molecular Function
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0045819 positive regulation of glycogen catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005964 phosphorylase kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xya, PDBe:8xya, PDBj:8xya
PDBsum8xya
PubMed38548794
UniProtP46020|KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Gene Name=PHKA1)

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