Structure of PDB 8xw7 Chain A

Receptor sequence
>8xw7A (length=501) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAKLIEAGA
NTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFE
GEAKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVL
VDDGKLGLRVVAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAE
RDNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETGNGHVQLFAKIE
NQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIIKKVNAAGK
VVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPL
ESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVKDATSSMDI
KLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTV
R
3D structure
PDB8xw7 Structural basis of nucleotide selectivity in pyruvate kinase.
ChainA
Resolution2.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E250 D274 E250 D274
BS02 FBP A S382 T384 T407 K408 T409 H411 T412 V490 R491 S382 T384 T407 K408 T409 H411 T412 V490 R491
BS03 OXL A K248 E250 A271 G273 D274 T306 K248 E250 A271 G273 D274 T306
BS04 ADP A P13 R54 N56 H59 E64 R95 K184 G341 N345 P13 R54 N56 H59 E64 R95 K184 G341 N345
Gene Ontology
Molecular Function
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xw7, PDBe:8xw7, PDBj:8xw7
PDBsum8xw7
PubMed39009072
UniProtQ8DQ84

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