Structure of PDB 8xuu Chain A

Receptor sequence
>8xuuA (length=431) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
TTTQSYTNSFTRGVYYPDKVFRSSVLHLTQDLFLPFFSNVTWFHAIDNPV
LPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVFIKVCEF
QFCNDGVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFK
IYSKHTPIIGRDFPQGFSALEPLVDLPIGINITRFQTLLALNRADYYVGY
LQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKFPNVTNLCPFHEVFN
ATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFT
NVYADSFVIKGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDS
KHSGNYDYWYRLFRKSKLKPFERDISTEIYQAGNKPCKGKGPNCYFPLQS
YGFRPTYGVGHQPYRVVVLSFELLHAPATVC
3D structure
PDB8xuu Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity
ChainA
Resolution3.69 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IDU A F168 R355 K356 R357 F116 R262 K263 R264
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0039660 structural constituent of virion
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
GO:0048018 receptor ligand activity
Biological Process
GO:0007165 signal transduction
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019081 viral translation
GO:0039587 suppression by virus of host tetherin activity
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0052170 symbiont-mediated suppression of host innate immune response
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
GO:0098670 entry receptor-mediated virion attachment to host cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0043655 host extracellular space
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0044228 host cell surface
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xuu, PDBe:8xuu, PDBj:8xuu
PDBsum8xuu
PubMed39071099
UniProtP0DTC2|SPIKE_SARS2 Spike glycoprotein (Gene Name=S)

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