Structure of PDB 8xq7 Chain A

Receptor sequence
>8xq7A (length=1041) Species: 7668 (Strongylocentrotus purpuratus) [Search protein sequence]
APKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLV
EEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFG
LVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGAS
KQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAV
AGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSG
VLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVT
QKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAV
IMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATT
IQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADW
DIATAACEISDPYSADELTLGERKSVCPGCKAMVPNEPSPREFADMMEEA
RLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLK
KSWQIKGIYPWLKRKLEDLISAFEVTINIAIVLNIVPIIMEFQKIEDALR
ISNYVFFVIYAIEAIVKILGSHWNKFDAFILVVALVDVVKLFRLLRGLRM
LRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDN
KKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSR
ETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNV
SWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYG
KVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDT
FTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDL
AESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYT
ATEEPRLFVVRNAEPILDGRLDVDSKRSLISITEISSNMCL
3D structure
PDB8xq7 Structures of a sperm-specific sodium-hydrogen exchanger.
ChainA
Resolution3.15 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A V989 L1008 F1032 G1043 M1045 G1046 R1053 N1054 R1097 V829 L848 F853 G864 M866 G867 R874 N875 R918
Gene Ontology
Molecular Function
GO:0015297 antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0030552 cAMP binding
GO:0030553 cGMP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006814 sodium ion transport
GO:0007338 single fertilization
GO:0019933 cAMP-mediated signaling
GO:0051453 regulation of intracellular pH
GO:0071805 potassium ion transmembrane transport
GO:0098719 sodium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0061827 sperm head

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xq7, PDBe:8xq7, PDBj:8xq7
PDBsum8xq7
PubMed38957574
UniProtA3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)

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