Structure of PDB 8xok Chain A

Receptor sequence
>8xokA (length=1206) Species: 9606 (Homo sapiens) [Search protein sequence]
QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH
LGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESA
KVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLY
FYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF
DQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKK
EISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAV
TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSD
GKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL
SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYE
KVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI
YLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI
LKDGKMVQKGTYTEFLKSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA
QVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVA
TVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNR
FSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGII
FIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQ
ELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTL
DAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAP
WEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIV
GRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEP
VLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESG
SNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFA
HCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ
QLGKAE
3D structure
PDB8xok The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport.
ChainA
Resolution2.84 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DU0 A F112 T133 A136 V140 F107 T128 A131 V135
BS02 DU0 A T226 A227 T221 A222
BS03 DU0 A P862 A865 P788 A791
BS04 DU0 A W863 I962 W789 I888
BS05 DU0 A L730 L771 L656 L697
BS06 DU0 A V726 V729 W733 A859 Q978 V652 V655 W659 A785 Q904
BS07 DU0 A V851 S855 A859 V777 S781 A785
BS08 DU0 A L215 I373 S377 L210 I368 S372
BS09 DU0 A N762 W763 G770 N688 W689 G696
Gene Ontology
Molecular Function
GO:0001409 guanine nucleotide transmembrane transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015216 purine nucleotide transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015432 ABC-type bile acid transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0034634 glutathione transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0002576 platelet degranulation
GO:0006805 xenobiotic metabolic process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0015721 bile acid and bile salt transport
GO:0015732 prostaglandin transport
GO:0015747 urate transport
GO:0032310 prostaglandin secretion
GO:0034775 glutathione transmembrane transport
GO:0055085 transmembrane transport
GO:0060271 cilium assembly
GO:0070730 cAMP transport
GO:0071716 leukotriene transport
GO:0098656 monoatomic anion transmembrane transport
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903790 guanine nucleotide transmembrane transport
Cellular Component
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031088 platelet dense granule membrane
GO:0098591 external side of apical plasma membrane

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:8xok, PDBe:8xok, PDBj:8xok
PDBsum8xok
PubMed38886124
UniProtO15439|MRP4_HUMAN ATP-binding cassette sub-family C member 4 (Gene Name=ABCC4)

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