Structure of PDB 8xmo Chain A

Receptor sequence
>8xmoA (length=1286) Species: 9606 (Homo sapiens) [Search protein sequence]
GPQSFVHFTKQSLALIEQRIAERKSKEPKPSSDLEAGKQLPFIYGDIPPG
MVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS
IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVKYTFTGIYTFESLV
KILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNNVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL
KHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDS
GQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL
RAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKEL
EFQQMLDRLKPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHP
MTEEFKNVLAIRNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT
LSLVELFLLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAFGNLTLV
LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFR
VLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS
SDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFGKIWWNIR
KTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKI
FTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSD
LGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFW
LIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRW
KNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLY
MYIYFVVFIIFGSFFTLNLFICVIIDNFNQQKKKLGGQDIFMTEEQKKYY
NAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTM
MVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFD
FVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRT
LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFE
TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGN
PSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATE
3D structure
PDB8xmo Dissection of the structure-function relationship of Na v channels.
ChainA
Resolution3.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LPE A Y1658 F1661 V1735 Y1176 F1179 V1253
BS02 LPE A K376 M379 K355 M358
BS03 LPE A S1206 A1210 S724 A728
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0006954 inflammatory response
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0019228 neuronal action potential
GO:0019233 sensory perception of pain
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0048266 behavioral response to pain
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0055085 transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0098870 action potential propagation
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0033268 node of Ranvier
GO:0034702 monoatomic ion channel complex
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043679 axon terminus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xmo, PDBe:8xmo, PDBj:8xmo
PDBsum8xmo
PubMed38381792
UniProtQ15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Gene Name=SCN9A)

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