Structure of PDB 8xlo Chain A

Receptor sequence
>8xloA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
EYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV
AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
EYASKGNLREYLQARRPPNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH
RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEA
LFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK
PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ
3D structure
PDB8xlo Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
ChainA
Resolution2.36 Å
3D
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LVQ A L484 G485 C488 A512 K514 E531 I545 V561 Y563 A564 G567 L630 D641 L23 G24 C27 A51 K53 E70 I84 V100 Y102 A103 G106 L159 D170
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8xlo, PDBe:8xlo, PDBj:8xlo
PDBsum8xlo
PubMed38432058
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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