Structure of PDB 8xgk Chain A

Receptor sequence
>8xgkA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
PKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVG
GLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVI
DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL
LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA
AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG
YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP
3D structure
PDB8xgk Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
ChainA
Resolution1.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LVB A R415 G462 R483 S508 G509 Y525 S555 A556 Y572 F577 S602 G603 R94 G141 R162 S187 G188 Y204 S234 A235 Y251 F256 S281 G282
External links
PDB RCSB:8xgk, PDBe:8xgk, PDBj:8xgk
PDBsum8xgk
PubMed38408347
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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