Structure of PDB 8xd0 Chain A

Receptor sequence
>8xd0A (length=417) Species: 49899 (Thermococcus profundus) [Search protein sequence]
EIDPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVK
VFTGFRVQHNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYG
GGKGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKI
MGWMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREA
AKALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNP
DGLDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVIT
EKNADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSY
FEWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVV
AVSRVYQAMKDRGWVKK
3D structure
PDB8xd0 CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase
ChainA
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A T191 Q218 Y220 G221 N222 D244 S245 K264 N281 A296 I297 N344 T189 Q216 Y218 G219 N220 D242 S243 K262 N279 A294 I295 N342
BS02 AKG A K69 K93 A143 S351 K67 K91 A141 S349
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8xd0, PDBe:8xd0, PDBj:8xd0
PDBsum8xd0
PubMed38750092
UniProtO74024|DHE3_THEPR Glutamate dehydrogenase (Gene Name=gdhA)

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