Structure of PDB 8xcp Chain A

Receptor sequence
>8xcpA (length=415) Species: 49899 (Thermococcus profundus) [Search protein sequence]
DPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKVF
TGFRVQHNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGGG
KGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIMG
WMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREAAK
ALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNPDG
LDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITEK
NADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYFE
WVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVAV
SRVYQAMKDRGWVKK
3D structure
PDB8xcp CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase
ChainA
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G219 Y220 G221 N222 D244 S245 N281 A296 I297 G215 Y216 G217 N218 D240 S241 N277 A292 I293
BS02 GGL A K69 M90 A143 P144 K65 M86 A139 P140
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8xcp, PDBe:8xcp, PDBj:8xcp
PDBsum8xcp
PubMed38750092
UniProtO74024|DHE3_THEPR Glutamate dehydrogenase (Gene Name=gdhA)

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