Structure of PDB 8xak Chain A

Receptor sequence

>8xakA (length=501) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

CLSKEQESIIKLAENGHNIFYTGSAGTGKSILLREMIKVLKGIYGRENVA
VTASTGLAACNIGGITIHSFAGIGLGKGDADKLYKKVRRSRKHLRRWENI
GALVVDEISMLDAELLDKLDFIARKIRKNHQPFGGIQLIFCGDFFQLPPV
SKDPNRPTKFAFESKAWKEGVKMTIMLQKVFRQRGDVKFIDMLNRMRLGN
IDDETEREFKKLSRPLPDDEIIPAELYSTRMEVERANNSRLSKLPGQVHI
FNAIDGGALEDEELKERLLQNFLAPKELHLKVGAQVMMVKNLDATLVNGS
LGKVIEFMDPETYFCYEALTNDPSMPPEKLETWAENPSKLKAAMEREQIG
EPVSPLDSSVFDFMKRVVLENIKRKEQLMQTIHQNSAGKRRLPLVRFKAS
DMSTRMVLVEPEDWAIEDENEKPLVSRVQLPLMLAWSLSIHKSQGQTLPK
VKVDLRRVFEKGQAYVALSRAVSREGLQVLNFDRTRIKAHQKVIDFYLTL
S

3D structure

PDB

8xak Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge.

Chain

Resolution

3.5 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	G291 T301 H303 S304 L310 R323 R324 R326 L329 R330 V385 S386 T464 R465 A679 I680 E681 K686 S703 H705 K706 R721 F723	G56 T66 H68 S69 L75 R88 R89 R91 L94 R95 V150 S151 T229 R230 A415 I416 E417 K422 S439 H441 K442 R457 F459
BS02	ADP	A	Q241 G261 G263 K264 S265 I266 F416 R417	Q6 G26 G28 K29 S30 I31 F181 R182
BS03	ALF	A	A260 E342 Q381 R417 G709 R734	A25 E107 Q146 R182 G445 R470

External links

PDB	RCSB:8xak, PDBe:8xak, PDBj:8xak
PDBsum	8xak
PubMed	39030241

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