Structure of PDB 8xa9 Chain A

Receptor sequence
>8xa9A (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
RVPQNWFPIFNPVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRM
ILELGEDGFKEYTSNVFLQGKRFHEALESILSSGYIESVQHILKDVSGVR
ALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQSTFDNPL
QVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTK
WLLRLEEYTEKKKN
3D structure
PDB8xa9 Structural basis of how MGME1 processes DNA 5' ends to maintain mitochondrial genome integrity.
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L125 R127 N128 L19 R21 N22
BS02 dna A S132 T134 Q138 Q145 F147 L148 L149 W152 V172 F173 G176 H180 G235 K253 T254 F266 Y275 S26 T28 Q32 Q39 F41 L42 L43 W46 V66 F67 G70 H74 G115 K133 T134 F146 Y155
BS03 CA A H180 D238 D251 W252 H74 D118 D131 W132
BS04 CA A H180 D238 H74 D118
External links
PDB RCSB:8xa9, PDBe:8xa9, PDBj:8xa9
PDBsum8xa9
PubMed38471810
UniProtQ9BQP7|MGME1_HUMAN Mitochondrial genome maintenance exonuclease 1 (Gene Name=MGME1)

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