Structure of PDB 8x2h Chain A

Receptor sequence

>8x2hA (length=2363) Species: 1292036 (Paraclostridium sordellii ATCC 9714)

MNLVNKAQLQKMAYVKFRIQEDEYVAILNALEEYHNMSESSVVEKYLKLK
DINNLTDNYLNTYKKSGRNKALKKFKEYLTMEVLELKNNSLTPVEKNLHF
IWIGGQINDTAINYINQWKDVNSDYTVKVFYDSNAFLINTLKKTIVESAT
NNTLESFRENLNDPEFDYNKFYRKRMEIIYDKQKHFIDYYKSQIEENPEF
IIDNIIKTYLSNEYSKDLEALNKYIEESLNKITANNGNDIRNLEKFADED
LVRLYNQELVERWNLAAASDILRISMLKEDGGVYLDVDMLPGIQPDLFKS
INKPDSITNTSWEMIKLEAIMKYKEYIPGYTSKNFDMLDEEVQRSFESAL
SSKSDKSEIFLPLDDIKVSPLEVKIAFANNSVINQALISLKDSYCSDLVI
NQIKNRYKILNDNLNPSINEGTDFNTTMKIFSDKLASISNEDNMMFMIKI
TNYLKVGFAPDVRSTINLSGPGVYTGAYQDLLMFKDNSTNIHLLEPELRN
FEFPKTKISQLTEQEITSLWSFNQARAKSQFEEYKKGYFEGALGEDDNLD
FAQNTVLDKDYVSKKILSSMKTRNKEYIHYIVQLQGDKISYEASCNLFSK
DPYSSILYQKNIEGSETAYYYSVADAEIKEIDKYRIPYQISNKRKIKLTF
IGHGKSEFNTDTFANLDVDSLSSEIETILNLAKADISPKYIEINLLGCNM
FSYSISAEETYPGKLLLKIKDRVSELMPSISQDSITVSANQYEVRINEEG
KREILDHSGKWINKEESIIKDISSKEYISFNPKENKIIVKSKYLHELSTL
LQEIRNNANSSDIDLEKKVMLTECEINVASNIDRQIVEGRIEEAKNLTSD
SINYIKNEFKLIESISDSLYDLKHQNGLDDSHFISFEDISKTENGFRIRF
INKETGNSIFIETEKEIFSEYATHISKEISNIKDTIFDNVNGKLVKKVNL
DAAHEVNTLNSAFFIQSLIEYNTTKESLSNLSVAMKVQVYAQLFSTGLNT
ITDASKVVELVSTALDETIDLLPTLSEGLPIIATIIDGVSLGAAIKELSE
TNDPLLRQEIEAKIGIMAVNLTAASTAIVTSALGIASGFSILLVPLAGIS
AGIPSLVNNELILQDKATKVIDYFKHISLAETEGAFTLLDDKIIMPQDDL
VLSEIDFNNNSITLGKCEIWRAEGGSGHTLTDDIDHFFSSPSITYRKPWL
SIYDVLNIKKEKIDFSKDLMVLPNAPNRVFGYEMGWTPGFRSLDNDGTKL
LDRIRDHYEGQFYWRYFAFIADALITKLKPRYEDTNVRINLDGNTRSFIV
PVITTEQIRKNLSYSFYGSGGSYSLSLSPYNMNIDLNLVENDTWVIDVDN
VVKNITIESDEIQKGELIENILSKLNIEDNKIILNNHTINFYGDINESNR
FISLTFSILEDINIIIEIDLVSKSYKILLSGNCMKLIENSSDIQQKIDHI
GFNGEHQKYIPYSYIDNETKYNGFIDYSKKEGLFTAEFSNESIIRNIYMP
DSNNLFIYSSKDLKDIRIINKGDVKLLIGNYFKDDMKVSLSFTIEDTNTI
KLNGVYLDENGVAQILKFMNNAKSALNTSNSLMNFLESINIKNIFYNNLD
PNIEFILDTNFIISGSNSIGQFELICDKDKNIQPYFIKFKIKETSYTLYV
GNRQNLIVEPSYHLDDSGNISSTVINFSQKYLYGIDRYVNKVIIAPNLYT
DEINITPVYKPNYICPEVIILDANYINEKINVNINDLSIRYVWDNDGSDL
ILIANSEEDNQPQVKIRFVNVFKSDTAADKLSFNFSDKQDVSVSKIISTF
SLAAYSDGFFDYEFGLVSLDNDYFYINSFGNMVSGLIYINDSLYYFKPPK
NNLITGFTTIDGNKYYFDPTKSGAASIGEITIDGKDYYFNKQGILQVGVI
NTSDGLKYFAPAGTLDENLEGESVNFIGKLNIDGKIYYFEDNYRAAVEWK
LLDDETYYFNPKTGEALKGLHQIGDNKYYFDDNGIMQTGFITINDKVFYF
NNDGVMQVGYIEVNGKYFYFGKNGERQLGVFNTPDGFKFFGPKDDDLGTE
EGELTLYNGILNFNGKIYFFDISNTAVVGWGTLDDGSTYYFDDNTAEACI
GLTVINDCKYYFDDNGIRQLGFITINDNIFYFSESGKIELGYQNINGNYF
YIDESGLVLIGVFDTPDGYKYFAPLNTVNDNIYGQAVKYSGLVRVNEDVY
YFGETYKIETGWIENETDKYYFDPETKKAYKGINVVDDIKYYFDENGIMR
TGLISFENNNYYFNEDGKMQFGYLNIKDKMFYFGKDGKMQIGVFNTPDGF
KYFAHQNTLDENFEGESINYTGWLDLDGKRYYFTDEYIAATGSLTIDGYN
YYFDPDTAELVVS

3D structure

• PDB: 8x2h Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.-
  3.4.22.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D546 H653	D546 H653

Gene Ontology

Molecular Function

• GO:0008234 cysteine-type peptidase activity
• GO:0008289 lipid binding
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding
• GO:0090729 toxin activity

Biological Process

• GO:0006508 proteolysis
• GO:0035821 modulation of process of another organism

Cellular Component

• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0020002 host cell plasma membrane
• GO:0030430 host cell cytoplasm
• GO:0044164 host cell cytosol
• GO:0044174 host cell endosome
• GO:0044175 host cell endosome membrane

External links

• PDB: RCSB:8x2h, PDBe:8x2h, PDBj:8x2h
• PDBsum: 8x2h
• UniProt: T0D3N5|TCSL3_PARS9 Cytotoxin-L (Gene Name=tcsL)