Structure of PDB 8x20 Chain A

Receptor sequence

>8x20A (length=553) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGL
KQKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLP
MGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRET
KLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQ
YALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS

3D structure

PDB

8x20 Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.

Chain

Resolution

2.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	W24 F61 V74 D76 R78 E89 I94 G152 P157 Y183 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 L289 K353 H361 K374 R448 T473 Q475 Y501	W24 F61 V74 D76 R78 E89 I94 G152 P157 Y183 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 L289 K353 H361 K374 R448 T473 Q475 Y501
BS02	XTE	A	R72 V111 A114 F115 M151 G152 M184 D185 K220	R72 V111 A114 F115 M151 G152 M184 D185 K220

External links

PDB	RCSB:8x20, PDBe:8x20, PDBj:8x20
PDBsum	8x20
PubMed	38977798
UniProt	P12497\|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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