Structure of PDB 8wzo Chain A

Receptor sequence

>8wzoA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]

IYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNR
MSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITC
TDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVA
GCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGL
LPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSARVDERAAEQARW
EAATTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGD
HWFDV

3D structure

PDB

8wzo Parkin in complex with phospho NEDD8

Chain

Resolution

2.25 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C253 H257 C289 C293	C112 H116 C148 C152
BS02	ZN	A	C365 C368 H373	C224 C227 H232
BS03	ZN	A	C446 C449 C457 H461	C286 C289 C297 H301
BS04	ZN	A	C166 C169 C196 C201	C25 C28 C55 C60
BS05	ZN	A	C238 C241 C260 C263	C97 C100 C119 C122
BS06	ZN	A	C332 C337 C352 C360	C191 C196 C211 C219
BS07	ZN	A	C418 C421 C436 C441	C258 C261 C276 C281
BS08	ZN	A	C150 C154 C212 H215	C9 C13 C71 H74

External links

PDB	RCSB:8wzo, PDBe:8wzo, PDBj:8wzo
PDBsum	8wzo
PubMed
UniProt	O60260\|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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