Structure of PDB 8wyy Chain A

Receptor sequence

>8wyyA (length=1069) Species: 36329 (Plasmodium falciparum 3D7)

IHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLDVE
QAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHTHL
NAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETEGWT
YEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYHEEM
KYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFSKNN
PTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHSEE
KENLVSVAWLLNPKVDLSLENPTDYFVLLIINNLLIHTPESVLYKALTDC
GLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVIMN
ALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLNYN
RDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEGDE
NYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEHLN
KFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKDNM
DVFLKKYVLKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYLNLF
KTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTDKYNAQ
ALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKINGMKTT
FSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAENDFKTL
ENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFEEND
KYIMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGEYLDP
SFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNLEKT
LATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLSFLR
LISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIVIITTKE
KANEYIANVDGEFKKVLIE

3D structure

• PDB: 8wyy Open falcilysin, from free falcilysin dataset
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H129 H133 E243	H69 H73 E183

External links

• PDB: RCSB:8wyy, PDBe:8wyy, PDBj:8wyy
• PDBsum: 8wyy
• UniProt: Q76NL8|FCLN_PLAF7 Falcilysin (Gene Name=FLN)