Structure of PDB 8wyx Chain A

Receptor sequence

>8wyxA (length=1070) Species: 36329 (Plasmodium falciparum 3D7)

EWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLD
VEQAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHT
HLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETEG
WTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYHE
EMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFSK
NNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHS
EEKENLVSVAWLLNPKVDLSLENPTDYFVLLIINNLLIHTPESVLYKALT
DCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVI
MNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLN
YNRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEG
DENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEH
LNKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKD
NMDVFLKKYVLKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYLN
LFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTDKYN
AQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKINGMK
TTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAENDFK
TLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFEE
NDKYIMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGEYL
DPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNLE
KTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLSF
LRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIVIITT
KEKANEYIANVDGEFKKVLI

3D structure

• PDB: 8wyx Partially closed falcilysin, from free falcilysin dataset
• Chain: A
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H129 H133 E243	H71 H75 E185

External links

• PDB: RCSB:8wyx, PDBe:8wyx, PDBj:8wyx
• PDBsum: 8wyx
• UniProt: Q76NL8|FCLN_PLAF7 Falcilysin (Gene Name=FLN)