Structure of PDB 8wy3 Chain A

Receptor sequence
>8wy3A (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGT
IKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ
KINELPT
3D structure
PDB8wy3 Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
ChainA
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHE A F83 V87 L92 L94 N140 I146 F24 V28 L33 L35 N81 I87
External links
PDB RCSB:8wy3, PDBe:8wy3, PDBj:8wy3
PDBsum8wy3
PubMed38175809
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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