Structure of PDB 8wxy Chain A

Receptor sequence
>8wxyA (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGT
IKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ
KINELPT
3D structure
PDB8wxy Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
ChainA
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XGN A W81 V87 L92 L94 N140 D144 I146 W22 V28 L33 L35 N81 D85 I87
External links
PDB RCSB:8wxy, PDBe:8wxy, PDBj:8wxy
PDBsum8wxy
PubMed38175809
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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