Structure of PDB 8wx7 Chain A

Receptor sequence
>8wx7A (length=485) Species: 9606 (Homo sapiens) [Search protein sequence]
TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAV
THIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHQLVIELKYPLNCADPT
SERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGSNDG
KSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQE
NKNKNRYKNILPFDHTRVVLHDSDYINANIIMPKKSYIATQGCLQNTVND
FWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKE
SAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
EVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDV
PKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB8wx7 Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
ChainA
Resolution2.02 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XD8 A T108 E110 R111 F113 H114 T219 E249 E250 T253 Q257 K492 Q495 T100 E102 R103 F105 H106 T206 E227 E228 T231 Q235 K452 Q455
External links
PDB RCSB:8wx7, PDBe:8wx7, PDBj:8wx7
PDBsum8wx7
PubMed39110625
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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