Structure of PDB 8wvb Chain A

Receptor sequence
>8wvbA (length=469) Species: 324833 (Streptomyces lasalocidi) [Search protein sequence]
TRSAVVLGGGMAGMLVSSMLARHVGSVTVIDRDAFPAGPDLRKGVPQARH
AHILWSGGARIVEELLPGTTDRLLGAGAHRIGIPDGQVSYTAYGWQHRFP
EAQFMIACSRALLDWTVREETLREERIALVEKTEVLALLGDAGRVTGVRV
RDQESGEEREVPADLVVDTTGRGSPMKRLLAELGLPAPEEEFVDSGMVYA
TRLFRAPEAAATNFPLVSVHADHRAGRPGCNAVLMPIEDGRWIVTVSGTR
GGEPPADDEGFARFARDGVRHPLVGELIAKAQPLTSVERSRSTVNRRLHY
DRLATWPEGLVVLGDAVAAFNPVYGHGMSAAAHSVLALRSQLGQRAFQPG
LARAAQRAIAVAVDDAWVLATSHDIGYPGCRTQTRDPRLTRHAGERQRVT
DLVGLTATRNQVVNRAAVALNTLSAGMASMQDPAVMAAVRRGPEVPAPTE
PPLRPDEVARLVSGAGVTA
3D structure
PDB8wvb Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G29 M30 A31 D50 R51 R61 G63 Q66 H69 H71 I72 R129 V154 T189 P194 D334 P341 G344 G346 M347 G10 M11 A12 D31 R32 R42 G44 Q47 H50 H52 I53 R110 V135 T170 P175 D315 P322 G325 G327 M328
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0071949 FAD binding
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8wvb, PDBe:8wvb, PDBj:8wvb
PDBsum8wvb
PubMed38069118
UniProtB5M9L6|LSD18_STRLS Putative epoxidase LasC (Gene Name=lsd18)

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