Structure of PDB 8wty Chain A

Receptor sequence
>8wtyA (length=540) Species: 9606 (Homo sapiens) [Search protein sequence]
FLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMEL
ALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLF
SSFTLNLPWTDCGHTWNSPNCTDPKSKYKFTPAAEFYERGVLHLHESSGI
HDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVL
LVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLI
AFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIE
DVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAV
ITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAA
GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPA
FLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKF
LSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
3D structure
PDB8wty Transport and inhibition mechanisms of the human noradrenaline transporter.
ChainA
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XEF A F72 V148 G149 Y152 F317 G320 F323 S419 F8 V84 G85 Y88 F240 G243 F246 S342
External links
PDB RCSB:8wty, PDBe:8wty, PDBj:8wty
PDBsum8wty
PubMed39085602
UniProtP23975|SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Gene Name=SLC6A2)

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