Structure of PDB 8wtw Chain A

Receptor sequence
>8wtwA (length=551) Species: 9606 (Homo sapiens) [Search protein sequence]
PRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLII
AGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNV
IIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKYSKYKFTPAAEFYER
GVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWIT
ATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIF
FSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILG
YMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALG
LDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGI
YVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLY
WRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSM
VLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLA
I
3D structure
PDB8wtw Transport and inhibition mechanisms of the human noradrenaline transporter.
ChainA
Resolution2.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W80 R81 D310 D473 K541 P542 T544 W26 R27 D244 D407 K475 P476 T478
BS02 0A1 A R81 F317 F323 R27 F251 F257
External links
PDB RCSB:8wtw, PDBe:8wtw, PDBj:8wtw
PDBsum8wtw
PubMed39085602
UniProtP23975|SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Gene Name=SLC6A2)

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