Structure of PDB 8wpu Chain A

Receptor sequence

>8wpuA (length=803) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRL
LSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGI
EKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSG
PDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALK
AGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQRPLCTGDENISS
VETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIK
KVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSI
VFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKG
IIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEI
EFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYL
LLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
LVFEAKWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIF
ITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSML
IFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILF
KPS

3D structure

• PDB: 8wpu Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	A	T145 G146 S147 A168 Y218 E297 A298 I416	T122 G123 S124 A145 Y195 E274 A275 I363
BS02	CA	A	S84 P85 A86 L87 L88 P89	S65 P66 A67 L68 L69 P70
BS03	YP4	A	Q681 F684 G685 I777 T780 W818 Y825 E837	Q628 F631 G632 I715 T718 W756 Y763 E775

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8wpu, PDBe:8wpu, PDBj:8wpu
• PDBsum: 8wpu
• PubMed: 37919470
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)