Structure of PDB 8wpg Chain A

Receptor sequence

>8wpgA (length=803) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDECSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSR
LLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPG
IEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSS
GPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFAL
KAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQERPLCTGDENI
SSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCAD
IKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDG
SIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTR
KGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAK
EIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELS
YLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNR
VLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGS
LMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWI
SFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTI
EEV

3D structure

• PDB: 8wpg Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	A	R66 T145 G146 S147 A168 S170 Y218 E297 A298	R47 T123 G124 S125 A146 S148 Y196 E275 A276
BS02	CA	A	I81 S84 L87 L88	I62 S65 L68 L69
BS03	YP4	A	F684 T780 F814 W818 Y825 E837	F633 T711 F745 W749 Y756 E768

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8wpg, PDBe:8wpg, PDBj:8wpg
• PDBsum: 8wpg
• PubMed: 37919470
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)