Structure of PDB 8wov Chain A

Receptor sequence

>8wovA (length=335) Species: 3702 (Arabidopsis thaliana)

SVLVTGGAGYIGSHTVLQLLEGGYSAVVVDNYDNSSAASLQRVKKLAGEN
GNRLSFHQVDLRDRPALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYN
NNIVGTVTLLEVMAQYGCKNLVFSSSATVYGWPKEVPCTEESPISATNPY
GRTKLFIEEICRDVHRSDSEWKIILLRYFNPVGAHPSGYIGEDPLGVPNN
LMPYVQQVAVGRRPHLTVFGTDYKTKDGTAVRDYIHVMDLADGHIAALRK
LDDSCEVYNLGTGNGTSVLEMVAAFEKASGKKIPLVMAGRRPGDAEVVYA
STEKAERELNWKAKNGIEEMCRDLWNWASNNPYGY

3D structure

• PDB: 8wov Cytosolic UDP-L-arabinose synthesis by bifunctional UDP-glucose 4-epimerases in Arabidopsis.
• Chain: A
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 5.1.3.2: UDP-glucose 4-epimerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDP	A	N183 N203 L204 T220 V221 F222 R235 Y237 V274 R297 D300	N180 N200 L201 T217 V218 F219 R232 Y234 V268 R291 D294
BS02	NAD	A	G9 G12 Y13 I14 D33 N34 D36 N37 S38 D63 F85 A86 G87 K89 N104 S127 S128 S129 Y153 K157 Y181 P184	G6 G9 Y10 I11 D30 N31 D33 N34 S35 D60 F82 A83 G84 K86 N101 S124 S125 S126 Y150 K154 Y178 P181

Gene Ontology

Molecular Function

• GO:0003978 UDP-glucose 4-epimerase activity
• GO:0016853 isomerase activity
• GO:1901149 salicylic acid binding

Biological Process

• GO:0006012 galactose metabolic process
• GO:0042546 cell wall biogenesis
• GO:0071555 cell wall organization

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:8wov, PDBe:8wov, PDBj:8wov
• PDBsum: 8wov
• PubMed: 38678521
• UniProt: Q9T0A7|UGE2_ARATH UDP-glucose 4-epimerase 2 (Gene Name=UGE2)