Structure of PDB 8wm9 Chain A

Receptor sequence
>8wm9A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
SDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFT
VLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCEPVLI
QEGLKNTGCAIIFLLLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMH
SSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVA
PLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVL
YTVPATIVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGM
WIWSAKTLHTWQKFYNRLVN
3D structure
PDB8wm9 Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.
ChainA
Resolution3.53 Å
3D
structure
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Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 Y01 A S344 S345 W352 S151 S152 W159
BS02 Y01 A R253 F257 L307 W352 R66 F70 L114 W159
BS03 Y01 A I267 T274 I80 T87
External links
PDB RCSB:8wm9, PDBe:8wm9, PDBj:8wm9
PDBsum8wm9
PubMed39223191
UniProtQ9ULV1|FZD4_HUMAN Frizzled-4 (Gene Name=FZD4)

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