Structure of PDB 8wlm Chain A

Receptor sequence
>8wlmA (length=382) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSVQVGLLFASKATVQ
LITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQ
GIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVL
YEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDP
YILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYL
IGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVG
FAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGA
IAKAIGFPWLMTIIGIIDILFAPLCFFLRSPP
3D structure
PDB8wlm Cryo-EM structure of human VMAT2 in presence of 5-HT in an outward-facing conformation
ChainA
Resolution3.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRO A L228 V232 N305 I308 E312 Y341 Y433 L136 V140 N213 I216 E220 Y249 Y341
Gene Ontology
Molecular Function
GO:0005335 serotonin:sodium:chloride symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015311 monoamine:proton antiporter activity
Biological Process
GO:0001975 response to amphetamine
GO:0002552 serotonin secretion by mast cell
GO:0002553 histamine secretion by mast cell
GO:0006836 neurotransmitter transport
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0042137 sequestering of neurotransmitter
GO:0051610 serotonin uptake
GO:0051615 histamine uptake
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:0099123 somato-dendritic dopamine secretion
GO:1902600 proton transmembrane transport
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Cellular Component
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0043195 terminal bouton
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
GO:0098691 dopaminergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wlm, PDBe:8wlm, PDBj:8wlm
PDBsum8wlm
PubMed
UniProtQ05940|VMAT2_HUMAN Synaptic vesicular amine transporter (Gene Name=SLC18A2)

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