Structure of PDB 8wky Chain A

Receptor sequence
>8wkyA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
QLFVSPVVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADML
VSVSLGFETIVITLLNSTDAQSFTVNIDNVIDSVICASLLASICSLLSIA
VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVI
ICLITMFFTMLALMASLYVHMFLMARLHGIDCSFWNESYLTGSRDERKKS
LLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIII
GKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFE
PFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILK
ALELSRSDLSKFRENCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPF
FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIINPLIYALRSQELRK
TFKEIICCYEFLEVLFQG
3D structure
PDB8wky Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
ChainA
Resolution2.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E100 I104 D122 D126 I129 C130 I185 S188 F261 H264 L265 Y268 F284 L288 E58 I62 D78 D82 I85 C86 I141 S144 F400 H403 L404 Y407 F423 L427
BS02 CA A E100 D122 D126 Y268 E58 D78 D82 Y407
External links
PDB RCSB:8wky, PDBe:8wky, PDBj:8wky
PDBsum8wky
PubMed38345933
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R)

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