Structure of PDB 8wgr Chain A

Receptor sequence
>8wgrA (length=548) Species: 9606 (Homo sapiens) [Search protein sequence]
GKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL
FYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWS
LYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLYSKYKFTPAAEFYERGVL
HLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATL
PYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSL
GAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMA
HEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDS
SMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVL
TLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRL
CWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLV
PIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
3D structure
PDB8wgr Molecular basis of human noradrenaline transporter reuptake and inhibition.
ChainA
Resolution2.75 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DSM A D75 A145 Y152 F317 S318 F323 V325 G423 D16 A86 Y93 F248 S249 F254 V256 G354
BS02 DSM A D342 T346 D273 T277
BS03 K A A73 V74 D75 N78 S318 N350 A14 V15 D16 N19 S249 N281
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005330 dopamine:sodium symporter activity
GO:0005334 norepinephrine:sodium symporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
GO:0043014 alpha-tubulin binding
GO:0046872 metal ion binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0007268 chemical synaptic transmission
GO:0009410 response to xenobiotic stimulus
GO:0015844 monoamine transport
GO:0015874 norepinephrine transport
GO:0035725 sodium ion transmembrane transport
GO:0048265 response to pain
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051620 norepinephrine uptake
GO:0070050 neuron cellular homeostasis
GO:0098810 neurotransmitter reuptake
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030424 axon
GO:0030672 synaptic vesicle membrane
GO:0032809 neuronal cell body membrane
GO:0042734 presynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wgr, PDBe:8wgr, PDBj:8wgr
PDBsum8wgr
PubMed39048818
UniProtP23975|SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Gene Name=SLC6A2)

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