Structure of PDB 8wgn Chain A

Receptor sequence
>8wgnA (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLV
IMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLT
EQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPE
IDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
3D structure
PDB8wgn Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors.
ChainA
Resolution2.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A V8 A9 I16 G17 G20 G53 K54 K55 T56 S59 L75 S76 R77 E78 R91 V115 G117 S118 T146 V8 A9 I16 G17 G20 G53 K54 K55 T56 S59 L75 S76 R77 E78 R91 V115 G117 S118 T146
BS02 WCQ A I7 V8 L22 E30 F31 F34 S59 P61 N64 V115 I7 V8 L22 E30 F31 F34 S59 P61 N64 V115
External links
PDB RCSB:8wgn, PDBe:8wgn, PDBj:8wgn
PDBsum8wgn
PubMed39250850
UniProtP00374|DYR_HUMAN Dihydrofolate reductase (Gene Name=DHFR)

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