Structure of PDB 8wfp Chain A

Receptor sequence
>8wfpA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
AAHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSSRS
3D structure
PDB8wfp Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer.
ChainA
Resolution1.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W414 V415 D416 Y485 L490 R516 F535 H538 K540 W44 V45 D46 Y115 L120 R146 F165 H168 K170
BS02 peptide A L490 L491 L120 L121
External links
PDB RCSB:8wfp, PDBe:8wfp, PDBj:8wfp
PDBsum8wfp
PubMed38105611
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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