Structure of PDB 8wfk Chain A

Receptor sequence
>8wfkA (length=546) Species: 9606 (Homo sapiens) [Search protein sequence]
LKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLI
FCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYN
VVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDARTSPSEEYWRLY
VLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF
PYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSL
GCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMA
NHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGT
QFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIY
WLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFF
QICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVL
CIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAP
3D structure
PDB8wfk Transport mechanism and pharmacology of the human GlyT1.
ChainA
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W5O A W70 Q313 Y316 W322 L471 D474 W27 Q245 Y248 W254 L403 D406
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015375 glycine:sodium symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0015816 glycine transport
GO:0035725 sodium ion transmembrane transport
GO:0046985 positive regulation of hemoglobin biosynthetic process
GO:0060012 synaptic transmission, glycinergic
GO:0060092 regulation of synaptic transmission, glycinergic
GO:0070455 positive regulation of heme biosynthetic process
GO:0150104 transport across blood-brain barrier
GO:1903804 glycine import across plasma membrane
GO:1904782 negative regulation of NMDA glutamate receptor activity
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030672 synaptic vesicle membrane
GO:0031045 dense core granule
GO:0032279 asymmetric synapse
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098688 parallel fiber to Purkinje cell synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wfk, PDBe:8wfk, PDBj:8wfk
PDBsum8wfk
PubMed38513663
UniProtP48067|SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (Gene Name=SLC6A9)

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