Structure of PDB 8wd4 Chain A

Receptor sequence
>8wd4A (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
SMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVA
IKELTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFG
SLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK
TPQHVKITDFGRAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADS
RPKFRELIIEFSKMARDPQRYLVIQGDERMHLPEEDMDDVVDADEYLIP
3D structure
PDB8wd4 Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W7W A L718 F723 A743 K745 C775 M790 Q791 L792 M793 P794 N842 L844 T854 L25 F30 A50 K52 C79 M94 Q95 L96 M97 P98 N146 L148 T158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8wd4, PDBe:8wd4, PDBj:8wd4
PDBsum8wd4
PubMed38065292
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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