Structure of PDB 8wd3 Chain A

Receptor sequence
>8wd3A (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
NPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRAS
YDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCT
PRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILD
LVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSW
YSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFD
KVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSC
RKDKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK
3D structure
PDB8wd3 The Crystal Structure of JMJD2A(M1-L359) from Biortus.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C234 H240 C306 C308 C226 H232 C298 C300
External links
PDB RCSB:8wd3, PDBe:8wd3, PDBj:8wd3
PDBsum8wd3
PubMed
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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