Structure of PDB 8w9w Chain A

Receptor sequence
>8w9wA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
RLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDS
VPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLR
CFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTC
GDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHE
HYSIDVFIAFYITTRLFLYYHTLANTRAYQQSRRARIWFPMFSFFECNVN
GTVPNEYCWPFSKP
3D structure
PDB8w9w Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
ChainA
Resolution3.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UJO A F163 G208 C212 F283 M285 D295 H301 F20 G65 C69 F140 M142 D152 H158
BS02 OPE A R275 I279 R132 I136
Gene Ontology
Molecular Function
GO:0016780 phosphotransferase activity, for other substituted phosphate groups

View graph for
Molecular Function
External links
PDB RCSB:8w9w, PDBe:8w9w, PDBj:8w9w
PDBsum8w9w
PubMed38388831
UniProtQ96LT4|SAMD8_HUMAN Sphingomyelin synthase-related protein 1 (Gene Name=SAMD8)

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