Structure of PDB 8w7d Chain A

Receptor sequence
>8w7dA (length=470) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGL
VSDVFEARHMQRLQGNMGIGHVRYPTSSASEAQPFYVNSPYGITLAHNGN
LTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIF
AAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDRTEYM
VASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFE
YVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETS
CDIALEIARILGKPYRQGFVKNRYVGRTFIMKSVRRKLNANRAEFRDKNV
LLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSA
TELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFN
GVYVTKDVDQGYLDFLDTLR
3D structure
PDB8w7d Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor
ChainA
Resolution2.81 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.14: amidophosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7TG A F255 Y259 D368 S369 V371 R372 G373 T374 T375 M410 F249 Y253 D355 S356 V358 R359 G360 T361 T362 M397
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004044 amidophosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009113 purine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w7d, PDBe:8w7d, PDBj:8w7d
PDBsum8w7d
PubMed38051581
UniProtP0AG16|PUR1_ECOLI Amidophosphoribosyltransferase (Gene Name=purF)

[Back to BioLiP]