Structure of PDB 8w71 Chain A

Receptor sequence
>8w71A (length=494) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
SMNGCDGDFKTPLGTVETRTMTAVLSPAAATERLISAVSELKSQPPSFSS
GVVRLQVPIDQQIGAIDWLQAQNEIQPRCFFSRRSDVGRPDLLLRNLVSV
AGIGSAVFFRDLDPFSHDDWRSIRRFLSSTSPLIRAYGGMRFDPNGKIAV
EWEPFGAFYFSVPQVEFNEFGGSSMLAATIAWDDELSWTLENAIEALQET
MLQVSSVVMKLRNRSLGVSVLSKNHVPTKGAYFPAVEKALEMINQKSSPL
NRVVLARNSRIITDTDIDPIAWLAQLQREGHDAYQFCLQPPGAPAFIGNT
PERLFQRTQLGVCSEALAATRPRAASSARDMEIERDLLTSPKDDLEFSIV
RENIREKLNGICDRVVVKPQKTVRKLARVQHLYSQLAGRLTKEDDEYKIL
AALHPTPAVCGLPAEEARLLIKEIESFDRGMYAGPIGFFGGEESEFAVGI
RSALVEKGLGALIYAGTGIVAGSDPSSEWNELDLKISQFTKSIE
3D structure
PDB8w71 Structural basis of chorismate isomerization by Arabidopsis ISOCHORISMATE SYNTHASE1.
ChainA
Resolution2.121 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.4.4.2: isochorismate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ISJ A R316 E366 A383 T384 H445 A472 Y496 I514 R515 A529 G530 K549 R252 E302 A319 T320 H381 A408 Y432 I450 R451 A465 G466 K485
BS02 MG A G532 E542 G468 E478
Gene Ontology
Molecular Function
GO:0008909 isochorismate synthase activity
GO:0016853 isomerase activity
Biological Process
GO:0006952 defense response
GO:0009409 response to cold
GO:0009617 response to bacterium
GO:0009627 systemic acquired resistance
GO:0009697 salicylic acid biosynthetic process
GO:0010118 stomatal movement
GO:0031348 negative regulation of defense response
GO:0042372 phylloquinone biosynthetic process
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050832 defense response to fungus
GO:0060866 leaf abscission
Cellular Component
GO:0009507 chloroplast
GO:0009536 plastid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w71, PDBe:8w71, PDBj:8w71
PDBsum8w71
PubMed38701037
UniProtQ9S7H8|ICS1_ARATH Isochorismate synthase 1, chloroplastic (Gene Name=ICS1)

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