Structure of PDB 8w6o Chain A

Receptor sequence
>8w6oA (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
RRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTAL
LPSLMLPMFGIMPKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVN
PAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIIKGHVTRKLTC
LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRCLNFGSWFTFSFPA
ALIILLLSWIWLQWLFLGAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLW
FSFATDSTVALLIGLLFFLIPAKTLTFDYSPLITWKEFQSFMPWDIAILV
GGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVAS
NPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIV
FSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAP
3D structure
PDB8w6o Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A S135 L138 S139 N140 G258 S116 L119 S120 N121 G167
BS02 NA A T485 A488 S489 N490 A532 T346 A349 S350 N351 A393
BS03 CLR A I458 L462 G466 I500 A507 I319 L323 G327 I361 A368
Gene Ontology
Molecular Function
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0015382 sodium:sulfate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8w6o, PDBe:8w6o, PDBj:8w6o
PDBsum8w6o
PubMed38552027
UniProtQ9BZW2|S13A1_HUMAN Solute carrier family 13 member 1 (Gene Name=SLC13A1)

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