Structure of PDB 8w6c Chain A

Receptor sequence
>8w6cA (length=530) Species: 9606 (Homo sapiens) [Search protein sequence]
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWC
TEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAV
EHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVP
IAHAVLDQLHSSQAKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQG
QINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNF
GIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREP
GFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENP
GKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKL
TPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHP
LYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGV
LVIALAINSWGIPLFSLHSFPSWAQSNTTA
3D structure
PDB8w6c Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A S136 I139 S140 N141 G239 S136 I139 S140 N141 G191
BS02 NA A T471 T474 S475 N476 A518 T423 T426 S427 N428 A470
BS03 Y01 A Y37 Y40 I65 M69 Y37 Y40 I65 M69
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015138 fumarate transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015361 low-affinity sodium:dicarboxylate symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w6c, PDBe:8w6c, PDBj:8w6c
PDBsum8w6c
PubMed38552027
UniProtQ13183|S13A2_HUMAN Solute carrier family 13 member 2 (Gene Name=SLC13A2)

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