Structure of PDB 8w5c Chain A

Receptor sequence
>8w5cA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPRPDQASTVAVK
MLKDDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG
NLREFLRARRPPGPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNV
LVTEDNVMKIADFGLLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTL
GGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPT
FKQLVEALDKVLLAVSE
3D structure
PDB8w5c Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
ChainA
Resolution2.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZO A L473 G474 V481 R483 A501 I534 C552 A553 A554 L619 L21 G22 V29 R31 A48 I78 C96 A97 A98 L151
External links
PDB RCSB:8w5c, PDBe:8w5c, PDBj:8w5c
PDBsum8w5c
PubMed38348819
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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