Structure of PDB 8w4s Chain A

Receptor sequence
>8w4sA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
ETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLV
QNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ
NKLTDLEILALLIAALSHDLDHRGVNNSSIMEHHHFDQCLMILNSPGNQI
LSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH
QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQKNKIPSMQVGF
IDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
3D structure
PDB8w4s Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.
ChainA
Resolution1.848 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H617 H653 D654 D764 H82 H118 D119 D214
BS02 AJR A Y612 L765 A779 F786 F787 I813 Q817 F820 Y77 L215 A229 F236 F237 I243 Q247 F250
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8w4s, PDBe:8w4s, PDBj:8w4s
PDBsum8w4s
PubMed37918035
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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