Structure of PDB 8w2g Chain A

Receptor sequence

>8w2gA (length=741) Species: 9606 (Homo sapiens) [Search protein sequence]

GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGG
ENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITN
LCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLV
GSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHC
GYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIII
AEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRIL
SSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAM
DDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAA
GMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRG
GSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARG
RYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGT
KRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMT
EKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQ
QGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGL
KKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ

3D structure

PDB

8w2g Structural basis for allosteric regulation of human phosphofructokinase-1.

Chain

Resolution

3.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	F6P	A	I165 D166 M208 E264 H298 R301	I153 D154 M196 E252 H286 R289
BS02	ADP	A	G24 R88 C89 G118 G120 G124 I127	G12 R76 C77 G106 G108 G112 I115
BS03	ADP	A	M174 D179 Y214 F308 D542 F670	M162 D167 Y202 F296 D530 F658
BS04	ADP	A	W227 L228 W382 K386 H390 K392	W215 L216 W370 K374 H378 K380
BS05	FBP	A	R470 T527 I528 S529 N531 M572 E628 R734	R458 T515 I516 S517 N519 M560 E616 R722
BS06	F6P	A	R201 R292	R189 R280
BS07	FBP	A	R565 R654	R553 R642

External links

PDB	RCSB:8w2g, PDBe:8w2g, PDBj:8w2g
PDBsum	8w2g
PubMed	39183237
UniProt	P17858\|PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type (Gene Name=PFKL)

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