Structure of PDB 8w1l Chain A

Receptor sequence
>8w1lA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
FIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLK
VAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVY
TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP
KNIYSIMQACWALEPTHRPTFQQICSFLQEQA
3D structure
PDB8w1l Identification of Selective Imidazopyridine CSF1R Inhibitors.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AE3 A L588 A614 M637 V647 T663 Y665 C666 C667 G669 L769 L785 G795 D796 F797 L26 A52 M75 V85 T101 Y103 C104 C105 G107 L137 L153 G163 D164 F165
External links
PDB RCSB:8w1l, PDBe:8w1l, PDBj:8w1l
PDBsum8w1l
PubMed38746878
UniProtP07333|CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (Gene Name=CSF1R)

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