Structure of PDB 8w13 Chain A

Receptor sequence
>8w13A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
VKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRF
HLGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKT
LYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQR
RGYGRFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSSVLLENLRD
FRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEH
LKSAQYKKPPITVDSVCLKWAPP
3D structure
PDB8w13 Identification of triazolyl KAT6 inhibitors via a templated fragment approach.
ChainA
Resolution1.81 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AEW A I317 Q324 R325 G327 G329 R330 S354 L356 S360 I142 Q149 R150 G152 G154 R155 S179 L181 S185
BS02 ZN A C210 C213 H226 C230 C35 C38 H51 C55
External links
PDB RCSB:8w13, PDBe:8w13, PDBj:8w13
PDBsum8w13
PubMed39236793
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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